geoffrey modest medical blogs

  A systematic review and meta-analysis found that riboflavin (vitamin B2) has significant benefit in migraine prophylaxis, including decreases in the number of migraine days, duration and frequency (see   migraine riboflavin prophy NutrNeurosci2022  in dropbox, or   doi.org/10.1080/1028415X.2021.1904542 )   Details :  -- nine articles were included in this systematic review and meta-analysis: eight randomized controlled trials and one controlled clinical trial were analyzed, with an overall total of 678 individuals     -- the overall sample sizes ranged from 26-130 adult subjects with varying doses of riboflavin     -- the intervention groups were on 400 mg of vitamin B2 daily  in eight studies , 100 mg in one -- four of the studies compared vitamin B2 to other migraine prophylactics (propranolol 80 mg, valproate 500 mg, metoprolol 200 mg or bisoprolol 10 mg, and aspirin 75 mg) -- overall these studies were felt to have l...

A recent Chinese study found that H pylori treatment, as well as long-term vitamin or garlic supplementation, reduced the risk of death from gastric cancer ( see  hpylori rx vitamins gastric cancer decrease bmj2019  in dropbox, or doi.org/10.1136/bmj.l5016 ) Details: -- 3365 residents in a high risk region for gastric cancer (Shandong province): 2258 were seropositive for H pylori antibodies and randomized to H pylori treatment, vitamin supplementation, garlic supplementation, or their placebos -- the remaining 1107 H pylori seronegative participants were randomized to the same vitamin supplementation, garlic supplementation, or their placebos -- those with H pylori treatment were given amoxicillin 1 g BID and omeprazole 20 mg BID for 2 weeks; the vitamin groups received vitamin C 250 mg, vitamin E 100IU, and selenium 37.5 µg (all BID); and the garlic groups received garlic extract 200 mg BID and steam-distilled garlic oil 1 mg BID. The vitamin and garlic gr...