geoffrey modest medical blogs

Although I just sent out a blog on cardiovascular problems with ADHD medications, another article just came out finding that all-cause mortality was actually significantly lower with ADHD stimulants (see   ADHD meds dec all-cause mortality JAMA2024 , or doi:10.1001/jama.2024.0851)   Details : -- 148,578 individuals aged 6 through 64 with ADHD were assessed in an observational nationwide cohort study; data were from 2007-2019, no ADHD medication dispensed prior to the diagnosis, and follow-up was until January 2021 -- 84,204 (56.7%) initiated an ADHD medication and 64,296 (43.3%) did not -- median age 17 yo, 41% female, education level: primary or lower secondary 17%/upper secondary 51%/postsecondary or postgraduate 32% -- accidental injuries 60%, depression 19%, nonalcohol drug use disorder 9%, suicide attempt history 8%, alcohol use disorder 8%, anxiety disorder 8%, personality disorders 4%, bipolar 3% ,  autism spectrum disorder 3%, eating disorder 2%, schizophreni...

  A recent large retrospective case-control study found that long-term exposure to ADHD medications was associated with an increased risk of hypertension and arterial disease (see   ADHD meds inc CVD risk JAMAPsych2024  in dropbox, or  doi:10.1001/jamapsychiatry.2023.4294)   Details : -- 278,027 individuals aged 6 to 64 years old with an diagnosis of incident ADHD were identified  and  10,388 also had cardiovascular disease (CVD) ,  from 2007 and 2021     -- data on ADHD and CVD diagnoses were obtained from the Swedish National Inpatient Register and  data on  ADHD medications dispensed were from the Swedish Prescribed Drug Register     -- cases selected included individuals with ADHD and an incident CVD diagnosis (ischemic heart disease, cerebrovascular disease, hypertension, heart failure, arrhythmias, thromboembolic disease, arterial disease)     --  these  10,388 individuals with...