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alcohol: the auto-brewery syndrome

  the auto-brewery syndrome (ABS) has hit the popular press https://www.nytimes.com/2026/04/03/well/autobrewery-syndrome.html ); this syndrome results from the gut microbiome producing excess ethanol and exceeding the hepatic ability to metabolize it. at times it results in individuals being accused of DUI (driving under the influence of alcohol) despite no alcohol consumption, having the breathalyzer test at high a level as 0.18% (see NatMicrobiology2026 in dropbox or https://doi.org/10.1038/s41564-025-02225-y and https://www.ncbi.nlm.nih.gov/books/NBK513346/ ). In addition, per the NY Times, an individual left his job after being stigmatized for smelling of alcohol, some individuals had frank alcohol intoxication and were felt to be liars by their doctors and spouses, and some even having alcohol withdrawal symptoms when not eating sufficient carbohydrates to stimulate the gut to produce ethanol Background (largely from the review article: auto-brewery syndrome review NatRe...
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long-term microbiome effects after taking even occasional antibiotics

  a very recent article evaluated three Swedish databases to evaluate antibiotic use and the subsequent development of long-term profound gut microbiome dysbiosis, which can be associated with many human diseases: see  antibiotic microbiome change 8 yrs NatureMed2026  in the dropbox, or  https://doi.org/10.1038/s41591-026-04284-y Details : -- this multicenter confounder-adjusted Swedish study involved 14,979 adults from 3 data sets, with assessment by fecal deep-shotgun metagenomics:     -- Swedish CArdiopulmonary bioImage Study ( SCAPIS , n= 8488), a random sample of residents in areas adjacent to 6 academic hospitals, between 2013 and 2018         -- mean age 57, 50% female, never smoker 53%/former smoker 34%/current smoker 12%         -- education: compulsory 9%/upper secondary 44%/university 46%         -- born in Scandinavia 90%  ...
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