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use of altered male mosquitoes to dec dengue transmission

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  a recent study found that mating Aedes aegypti female mosquitoes that can carry dengue virus with Wolbachia-infected   males dramatically decreased human dengue infections  (see  dengue mosquitos infected with other dec dengue transmission  in dropbox, or DOI: 10.1056/NEJMoa2503304) Details : -- this study in Singapore, a tropical city-state, was designed to make female A. aegypti mosquitoes infertile by releasing male infected with the wAlbB strain of wolbachia bacteria, in 2022 during weeks 30 to 37. The trial was concluded in week 37 in 2024. (these weeks were considered to be "epidemiologic weeks" to compare data over time without calendar date fluctuations) -- this was a cluster-randomized trial with test-negative controls performed in 15 geographic population clusters. All clusters were in urban areas; 8 clusters received deployments of male wolbachia-infected mosquitoes (intervention clusters) and 7 clusters received no deployments (contr...
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CAD plus atrial fib: should we use aspirin plus anticoag?

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  A recent study found that aspirin was actually harmful in patients with chronic coronary syndrome who were at high atherothrombotic risk and were on long-term anticoagulation, in the AQUATIC trial (Assessment of Quitting versus Using Aspirin Therapy in Patients with Stabilized Coronary Artery Disease after Stenting Who Require Long-Term Oral Anticoagulation. a bit of a mouthful....) in this French study: see   aspirin plus anticoag NEJM2025  in dropbox, or DOI: 10.1056/NEJMoa2507532     -- "chronic coronary syndrome" is the new name for "stable coronary artery disease" Details : -- 872 adults were eligible who had documented chronic coronary syndrome with previous coronary stent implantation more than 6 months before enrollment, had features of high residual atherothrombotic risk, and were receiving an oral anticoagulant (either a direct oral anticoagulant DOAC or a vitamin K antagonist VKA) for any reason.     --inclusion criteria: high-ri...
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