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Fallopian tube excision prevents ovarian cancer

  A recent article in the NY Times strongly suggested that ovarian cancer is very largely a result of a cancer spreading from the fallopian tubes: (see https://www.nytimes.com/2026/07/28/health/ovarian-cancer-fallopian-tubes.html ), and thanks to Steve Leiner for bringing that to my attention. it turns out, unbeknownst to me, that this focus on fallopian tubes has been known and promulgated for more than 20 years. Below is from a brief Viewpoint in JAMA that summarizes this issue, along with a more extensive review of some recent articles: see ovarian ca dec with salpingectomy JAMA2023 in dropbox, or doi:10.1001/jama.2023.6979 Details and Commentary: -- 20,000 women are diagnosed with ovarian cancer in the US annually. 80% have high-grade serous carcinomas, almost all with no known cancer risk factors, and these patients overwhelmingly present with widely metastatic disease at symptom onset and die within 5 years of diagnosis     -- ovarian cancer is the fifth-leading c...
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semaglutide beneficial in frail individuals

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  A recent post hoc analysis of a study of semaglutide for weight loss patients found that frail patients did at least as well as patients who were not frail: see semaglutide safe in frail JAMAcardiol2026 in dropbox, or doi:10.1001/jamacardio.2026.3566   Details : -- 17,604 participants were involved in the SELECT trial of participants who had a BMI of at least 27 and established cardiovascular disease but without diabetes, who were randomized to semaglutide 2.4mg weekly vs placebo     -- 12,732 patients (72.3%) were male and 4872 (27.7%) were female -- a 31-item frailty index (FI) was assessed using the Rockwood cumulative deficit approach; patients were categorized as not frail (FI up to 0.210), more frail (FI of 0.211 to 0.310), and most frail (FI at least 0.311)     -- the Rockwood cumulative deficit assesses 30 to 40 diverse variables covering multiple organ systems, focusing on the presence of disease, mobility impairment, and abnormal lab v...
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