Posts

diabetes add PCSK9 decreases heart probs primary prevention

Image
  A very recent study, the VESALIUS-CV (Effect of Evolocumab in Patients at High Cardiovascular Risk without Prior Myocardial Infarction or Stroke) trial found that adding the PCSK9 inhibitor evolocumab to patients with diabetes with no prior history of ASCVD (atherosclerotic cardiovascular disease) prevented the first major cardiovascular event (see   diabetes primary ASCVD prevention with PCSK9 JAMA2026  in dropbox, or doi:10.1001/jama.2026.3277)   Details : -- VESALIUS-CV was a randomized, double-blind, placebo-controlled trial of evolocumab conducted across 774 sites in 33 countries, enrolling 12,257 patients with diabetes but no prior myocardial infarction or stroke, LDL-C level 90mg/dL or greater, and qualifying atherosclerosis or high-risk diabetes. This current study was a prespecified subgroup analysis to examine outcomes in patients without known significant atherosclerosis     --none of the patients had prior arterial revascularization, arte...
Post a Comment
Read more

2026 ACC cardiology guidelines for lipid management

Image
  a very multicenter 2026 clinical practice guideline was just released on the management of dyslipidemia from the ACC/AHA (American College of Cardiology and the American Heart Association), subsequently endorsed by the AACVPR/ABC/ ACPM/ADA/AGS/APhA/ASJPC/NLA/PCNA (see the article for interpretation of this alphabet soup):see   lipid management ACC guideline2026  in dropbox, or DOI: 10.1161/CIR.0000000000001423. This is a review of a 123-page document which raises many questions. so the blog is pretty long but i think it includes lots of new and useful information Details : -- the basis for these guideline recommendations was from a comprehensive literature search done in late 2024 -- the focus of the search was the evaluation, management, and monitoring of individuals with dyslipidemias, including high blood cholesterol, hypertriglyceridemia, and elevated lipoprotein(a) -- a summary of the top take-home messages, per the guideline document: treat dyslipidemia earli...
Post a Comment
Read more