Posts

PPIs associated with COPD and asthma exacerbations

Image
  A recent Belgian study found that the use of proton pump inhibitors (PPIs) is associated with increased exacerbations of COPD and asthma (which they refer to as chronic obstructive airway diseases, COADs) in a dose-response way: see copd inc with PPIs Chest2026 in dropbox, or DOI: https://doi.org/10.1016/j.chest.2026.01.002   Details : -- 932,135 patients (with a total of 1,084,446 person-years of follow-up) were identified using the Belgian nationwide claims-based data of adult patients receiving long-term medication for COADs (ie, having at least two dispensings of medication for obstructive lung diseases) between 2017 and 2022 -- patients on histamine type 2 receptor antagonists (H2RAs) were excluded (at that time there was a carcinogen impurity found in ranitidine, the most prescribed H2 blocker, that was taken off the market), -- 416,087 patients (44.6%) were also receiving PPIs: -- mean age 61, 54% female, 29% low socioeconomic status (assessed by their medical cover...
Post a Comment
Read more

beta blockers not help if MI and normal LVEF

Image
  Contrary to several current guidelines, prescribing beta-blockers in patients with acute MI and preserved ejection fraction does not seem to provide any benefit (see MI nl EF beta block not help NEJM2026 in dropbox, or DOI: 10.1056/NEJMoa2512686 ) Details : -- this study is a preplanned meta-analysis of five prior open-label trials that randomly assigned patients with a recent myocardial infarction, no other indications for beta-blocker therapy, and a left ventricular ejection fraction (LVEF) of at least 50% to receive either beta-blocker therapy or no beta-blocker therapy:     -- the REBOOT study (Treatment with Beta-Blockers after Myocardial Infarction without Reduced Ejection Fraction): 6459 patients     -- the REDUCE-AMI study (Randomized Evaluation of Decreased Usage of Beta-Blockers after Acute Myocardial Infarction): 4967 patients     -- the BETAMI study (Norwegian Beta-Blocker Treatment after Acute Myocardial Infarction in Revascularized P...
Post a Comment
Read more