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aggressive LDL lowering and coronary plaque regression modified

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  A new study confirmed that very intensive lipid-lowering led to atherosclerotic plaque regression in patients who had not been on statins previously: see statin intensive plaque regression JAMANetwork2026 in dropbox, or doi:10.1001/jamacardio.2026.4788 Details: --this study was a prespecified analysis of the FLOWPROMOTE study, a randomized clinical trial performed in 3 Danish hospitals that had significant experience in conducting coronary CTA (coronary computed tomography angiography) as well as FFR-CT (flow fractional reserve)     -- individuals were eligible to be included if they had coronary CTA >50% and FFR-CT <0.8 and had not been on chronic statins     -- the initial coronary CTA at the time of diagnosis by was repeated at 9 and 18 months     -- the goal of this study was to assess the association between achieved LDL cholesterol levels and atherosclerotic plaque regression     -- this study was done from May 2020 to Oc...
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high dose flu vaccine decreases severe cardiac and respiratory diseases

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   a recent study found that high dose flu vaccine in older adults was associated with of a decrease in a wide array of severe cardiovascular and respiratory outcomes, including hospitalization for heart failure: see flu vaccine high dose dec card dz Circ2026 in dropbox, or DOI: 10.1161/CIRCULATIONAHA.125.077801 Details: -- this study was a prespecified secondary analysis of the unblinded FLUNITY-HD (Pooled Analysis of Methodologically Harmonized Pragmatic Randomized Trials of High-Dose vs. Standard-Dose Influenza Vaccine Against Severe Clinical Outcomes), which had individual-level pooled data sets integrating two methodologically harmonized (ie similar approaches), pragmatic, individually randomized trials conducted in Denmark and Spain, to assess the relative vaccine effectiveness of the high-dose inactivated influenza vaccine (HD-IIV) versus the standard-dose inactivated influenza vaccine (SD-IIV) against severe cardiovascular and respiratory outcomes (for the FLUNITY-HD ...
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sugar and artificial sweeteners both increase liver cancer

  a recent study found that drinking either artificially sweetened or sugar-sweetened beverages was associated with increased risk of liver cancer: see artificial sweeteners and sugar inc liver cancer JAMA2026 in dropbox, or doi:10.1001/jamanetworkopen.2026.17754 Details : -- analysis of 11 prospective cohort studies assessed the relationship between the intake of artificially sweetened beverages (ASBs) and sugar-sweetened beverages (SSBs) with the subsequent development of liver cancer in adults     -- 10 US cohorts and 1 European cohort:         -- National Institutes of Health-AARP (NIH-AARP)         -- Agricultural Health Study (AHS)         -- Cancer Prevention Study-II Nutrition Cohort (CPS-II)         -- European Prospective Investigation Into Cancer and Nutrition (EPIC)         -- Health Professionals Follow-Up Study (HPFS)         -- Nurses’ He...
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