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antibiotic resistance genes in newborns!!

  A news release last week published an oral presentation from the European Society of Clinical Microbiology and Infectious Diseases at the ESCMID Global 2026 meeting in Munich:   https://www.eurekalert.org/news-releases/1124038  . thanks again to Paul Susman for bringing this to my attention. Summary of the presentation : -- meconium samples of 105 infants admitted to a neonatal ICU within the first 72 hours of life, based on data from July 2024 to July 2025 -- studies done 2 decades ago have documented that meconium is not sterile , contrary to prior belief,  which suggests that the neonatal gut may well be exposed to maternal bacteria during pregnancy     -- the concern was that early microbial exposure could spread antibiotic resistance through maternal transmission, delivery mode, and very early hospital exposures -- the researchers screened meconium samples from these infants for 56 different resistance genes associated with commonly used antibiotics ...
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hypercortisolism in patients with diabetes

  A recent article explored the relationship between difficult-to-control diabetes and endogenous hypercortisolism, finding improved glycemic control with the use of mifepristone   in the CATALYST study (see   dm hypercortisolism mifepristone rx DiabCare2025  in dropbox, or   https://doi.org/10.2337/dc25-1055 ), in the CATALYST study Details : -- 136 individuals who had type II diabetes (T2D) and hemoglobin A1c between 7.5% and 11.5% on multiple medications were then randomized in this prospective, multicenter, double-blind study of  the glucocorticoid receptor antagonist mifepristone (300 to 900 mg daily) vs placebo for 24 weeks, stratified by the presence or absence of an adrenal imaging abnormality     -- specifically, patients had to be on least three glucose lowering medications, or taking insulin and any other glucose lowering medication(s), or taking at least two glucose lowering medications and having at least one microvascular or mac...
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