semaglutide beneficial in frail individuals
A recent post hoc analysis of a study of semaglutide for weight loss patients found that frail patients did at least as well as patients who were not frail: see semaglutide safe in frail JAMAcardiol2026 in dropbox, or doi:10.1001/jamacardio.2026.3566 Details : -- 17,604 participants were involved in the SELECT trial of participants who had a BMI of at least 27 and established cardiovascular disease but without diabetes, who were randomized to semaglutide 2.4mg weekly vs placebo -- 12,732 patients (72.3%) were male and 4872 (27.7%) were female -- a 31-item frailty index (FI) was assessed using the Rockwood cumulative deficit approach; patients were categorized as not frail (FI up to 0.210), more frail (FI of 0.211 to 0.310), and most frail (FI at least 0.311) -- the Rockwood cumulative deficit assesses 30 to 40 diverse variables covering multiple organ systems, focusing on the presence of disease, mobility impairment, and abnormal lab v...