GLP-1 agonists: improve skeletal muscle??
A recent article evaluated the effects of GLP-1 receptor agonists on free-fat mass loss as associated with the attendant weight loss , in a review of 28 trials (see GLP-1 and weight loss composition DiabObesMetab2024 in dropbox , or DOI: 10.1111/dom.15913) Introduction: -- there are 2 incretins (GLP-1 and GIP) that are secreted in response to nutrients (glucose and other carbohydrates, fats, and proteins) -- GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) have somewhat different effects in the body but are synergistic in leading to pancreatic insulin release -- GLP-1 receptors are located throughout the body (as are GIP receptors, but this blog and discussion will focus on the GLP-1's) -- here is a graphic which shows the various targets and related relevant systemic effects of these incretins: -- GLP-1 receptors are an important part of the G prote...