Prostatectomy not help for localized ca
The 19.5 year follow-up of the PIVOT study (Prostate Cancer Intervention vs Observation Trial) confirmed their prior observations at the 12-year mark, showing that for men with localized prostate cancer, surgery was not significantly associated with decreases in all-cause or prostate cancer specific mortality (see Wilt TJ. N Engl J Med 2017;377:132). Details: -- From 1994 to 2002, 731 men with localized prostate cancer were randomized to radical prostatectomy vs observation. This study provides patient-reported outcomes data through 2014 -- Mean age at the beginning of the study was 67, PSA 7.8. All patients had to have histologically-confirmed, clinically localized prostate cancer (stage TI-T2NxM0) of any grade diagnosed in the prior 12 months, and PSA needed to be <50, age <75, negative results on bone scan for metastatic disease, and life expectancy of >10 years -- Mortality outcomes were assessed loca...