Covid human volunteer challenge study
The first study was just reported on viral kinetics and other outcomes in volunteers inoculated with SARS-CoV-2 virus (see covid human challenge UK NatMed2022 in dropbox, or doi.org/10.1038/s41591-022-01780-9 ) Details: --36 volunteers aged 18 to 29, without evidence of prior infection or vaccination, were inoculated with 10TCID 50 of pre-alpha wild type (i.e. the original) of SARS-CoV-2 intranasally, in an open-label nonrandomized study -- TCID 50 is the Median Tissue Culture Infectious Dose; and, 10 TCID 50 is a low starting inoculum dose -- these individuals had none of the following risk factors for severe covid: low or high BMI; abnormal labs including CBC, renal or liver function, clotting, or viral serology to exclude other viruses; spirometry; echocardiography; chest x-ray -- mean age 22, 75% male, 92% white, BMI 23 -- after inoculation, the volunteers were housed in a high-containment quarant...