H Pylori: antimicrobial resistance in Rhode Island
A study fro m Rhode Island documented antibiotic resistance to H Pylori (thanks to Boris Skurkovich for bringing this to my attention): see h pylori resistance rhode island Gastro2021 in dropbox or doi:10.1053/j.gastro.2021.02.014. Details : -- 189 patients from 2 hospitals in Rhode Island (total 1000 beds), who had positive gastric biopsies for H Pylori and assessed its eradication after treatment -- eradication determined by urea breath test in 51%, stool antigen in 40%, and biopsy in 10% -- mean age 45, 68% male, 29% white/25% Black/ 44% Latinx -- treatment duration 14 days (the standard now) in 91% -- antimicrobial resistance was determined through the PyloriAR assay, which evaluates DNA mutations in the H Pylori genome associated with fluoroquinolones, metronidazole, clarithromycin, ampicillin, tetracycline and rifabutin, using “next-generation sequencing” -- H Pylori presence was determined by quantitative real-time PC...