geoffrey modest medical blogs

Although I just sent out a blog on cardiovascular problems with ADHD medications, another article just came out finding that all-cause mortality was actually significantly lower with ADHD stimulants (see   ADHD meds dec all-cause mortality JAMA2024 , or doi:10.1001/jama.2024.0851)   Details : -- 148,578 individuals aged 6 through 64 with ADHD were assessed in an observational nationwide cohort study; data were from 2007-2019, no ADHD medication dispensed prior to the diagnosis, and follow-up was until January 2021 -- 84,204 (56.7%) initiated an ADHD medication and 64,296 (43.3%) did not -- median age 17 yo, 41% female, education level: primary or lower secondary 17%/upper secondary 51%/postsecondary or postgraduate 32% -- accidental injuries 60%, depression 19%, nonalcohol drug use disorder 9%, suicide attempt history 8%, alcohol use disorder 8%, anxiety disorder 8%, personality disorders 4%, bipolar 3% ,  autism spectrum disorder 3%, eating disorder 2%, schizophreni...

blog from 4/4/20 2 articles came out of note on a more detailed analysis of the association between underlying health conditions and Covid-19 , one from China and one from the US .   CHINA:  see  covid comorbidities and outcomes eurrespj2020  in dropbox, or  doi :   10.1183/13993003.00547-2020      Details: -- 1590 laboratory-confirmed hospitalized patients from 575 hospitals in 31 provinces across China -- mean age 50, 43% female, severe cases in 16% -- most common symptoms on or after hospitalization: fever 88%, dry cough 70%, fatigue 43%, productive cough 36%. Abnormal chest CTs in 70% -- data analyzed between December 11, 2019 and January 31, 2 020 -- composite endpoint: admission to ICU, invasive ventilation, or death -- median follow-up: 10 days   Results: -- composite endpoint: 131 patients (8%)      -- death: 50 patients (6%)      -- ICU: 99 patients (6%)      -- invasiv...