?best to take BP meds at night
?best to take BP meds at night G Geoff A. Modest, M.D. Mon 11/18/2019 7:26 AM Geoff A. Modest, M.D. A recent Spanish study (the Hygia Chronotherapy Trial) was brought to my attention (thanks to Jon Pincus) confirming the importance of nighttime antihypertensive medication as a means to decrease adverse cardiovascular outcomes (see htn bedtime dec cvd risk ESC2019 in dropbox, or doi:10.1093/eurheartj/ehz754.) Details: -- 19,084 hypertensive pat ients were randomized to taking their entire dose of antihypertensive medications at bedtime versus upon awakening -- 56% men, mean age 61, BMI 30, nighttime sleep duration 9 hours, diabetes 24%/OSA 4%/smoking 16%/obesity 43%/CKD 30%/prior CVD event 10%/duration of known hypertension 9 years -- baseline office blood pressure 149/86 mmHg, 48-hour mean pressure 132/77 mmHg, non-dippers (those whose blood pressure did...