geoffrey modest medical blogs

  A recent open-label, pragmatic randomized trial of patients with heart failure found no difference if using torsemide versus furosemide as the loop diuretic ( see chf torsemide vs furos JAMA Card2023  in dropbox, or   https://jamanetwork.com/journals/jama/fullarticle/2800428?guestAccessKey=5afad846-ee09-457e-83c5-1cef2f98e0ad&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamacardiology&utm_content=olf&utm_term=012523   )   Details :  -- 2859 participants, all hospitalized with heart failure at 60 hospitals in the United States, were recruited from June 2018 through March 2022      -- they had either newly diagnosed heart failure (30% of them), the rest had chronic heart failure and were hospitalized for heart failure in the past year -- mean age 64, 35% female, 58% white/33% Black/5% Hispanic  -- left ventricular ejection fraction>50% in 24% of the patients/  <40% in 70%/41-49% in 6% (but the latter had only 81 people)  -- loop diuretic

  There was a discouraging letter to the editor in JAMA recently, finding increased cervical cancer incidence in the US (see  cervical ca incidence inc JAMA2022  in dropbox or  doi:10.1001/jama.2022.17806 )      Details :  -- data from the 2001 to 2019 National Program of Cancer Registries (NPCR) and the Surveillance Epidemiology and End Results (SEER) databases. Data included all 50 states and covers 98% of the US population  -- based on this, they calculated the annual percent changes in the incidence rates and trends of cervical cancer screening by five-year age groups; this assessment was hysterectomy-corrected based on surveys of the general hysterectomy rates from the Behavioral Risk Factor Surveillance System database    Results :  -- from 2001 to 2019, 227,062 cervical cancer cases were reported  -- hysterectomy-corrected cervical cancer incidence declined from 12.39 per 100,000 in 2001 to 9.80 per 100,000 in 2019, with an annual percent change (APC) of -1.2%; the most dramatic