eGFR: not such a great estimate of renal function
An important article was just published finding that on an individual level, the calculated eGFR can vary pretty dramatically from the measured one, potentially affecting issues ranging from the validity of eGFR for renal dosing of medications, referrals to renal clinic, anxiety in patients (and providers), and perhaps invasive procedures (such as AV fistula surgery, kidney biopsies, etc), see ckd eGFR not so accurate AIM2022 in dropbox, or doi:10.7326/M22-06 Details: -- a cross-sectional study of 4 US community-based epidemiologic cohort studies assessing both measured GFR (mGFR) and estimated GFR (eGFR), including 3223 participants -- the studies included GENOA (Genetic Epidemiology Network of Arteriopathy), ECAC (Epidemiology of Coronary Artery Calcification), ALTOLD (Assessing Long Term Outcomes in Living Kidney Donors), and CRIC (Chronic Renal Insufficiencies Cohort). The first three of these had participants who were not s...