obesity: weight changes when stop tirzepatide
An updated study assessed the longer-term effects of the medication tirzepatide on weight reduction, comparing those who continued the tirzepatide versus those who stopped it, in the SURMOUNT4 trial (see obesity tirzepatide discont and inc wt JAMA 2024 in dropbox, or doi:10.1001/jama.2023.24945 ) Details : -- this is a phase 3, randomized withdrawal clinical trial in 70 sites in 4 countries (Argentina, Brazil, Taiwan and the US) from 2021 to 2023, with two phases: -- all patients took open-label tirzepatide weekly to their maximum tolerated dose, in this lead-in period lasting until week 36 -- initiation for tirzepatide therapy was by the standard approach: 2.5 mg weekly initially with an increase of 2.5 mg every four weeks until the maximum tolerated dose of up to 15 mg -- 670 patients at week 36 were then randomized to continuing to receive tirzepatide versus a ...