geoffrey modest medical blogs

  A secondary analysis of the CONNECT trial, that stands for (a bit of a stretch...)  “A Randomized Comparison of Long-Term Vascular Healing Between Biodegradable Polymer vs Durable Polymer Everolimus Eluting Stents in Acute ST-Elevation Myocardial Infarction” found that a lower target LDL level was associated with decreased neoatherosclerosis, which is associated with subsequent stent failure (see   LDL goal after stent JAMAcardiol2025  in dropbox, or doi:10.1001/jamacardio.2025.4723)   Details : -- the CONNECT trial was a prospective, multicenter, open-label, assessor-blind, randomized clinical trial to investigate the association between achieving guideline-endorsed target LDL levels with long-term neoatherosclerosis formation after current-generation drug-eluting stent implantation. This trial was conducted in 7 centers in 2 countries (Switzerland and Japan)     -- patients at least 18 years old were eligible if they presented with a...

  A recent study found that in patients with atherosclerotic cardiovascular disease (ASCVD), there was a progressive increase in recurrent cardiac events as lipoprotein(a) levels increased: see   Lp(a) recurrent ASCVD EuropHeartJ 2025  in dropbox. or   doi.org/10.1093/eurheartj/ehaf297 )   Details : -- they accessed the Family Heart Database of US medical claims from 340 million adults between 2012-2022, representing at least 1/2 of the national census population, with lipid data available for about 1/3 of them -- these medical claims included medication use, diagnoses, procedures, and surgeries     -- 273,770 people had diagnosed ASCVD as well as lipoprotein(a) levels, also referred to as Lp(a), measured         -- ASCVD was defined as: evidence of an MI, other acute coronary syndromes, percutaneous coronary interventions (PCI), CABG, stable angina, ischemic stroke, other cerebral vascular disease, TIA, peripheral va...