geoffrey modest medical blogs

  Another article recently found profound neuroinflammatory increases during the Covid pandemic, this time in never-infected persons ( see  covid neuroinflam in noninfected BrainBehavImmun2022  in dropbox, or doi.org/10.1016/j.bbi.2022.02.018 ) Details  (see the article for many more details): -- 57 "pre-pandemic" and 15 "pandemic" patients were compared, based on data sets from other studies -- multimodal PET/MRI imaging was used to investigate brain levels of two inflammatory markers: 18 kDa translocator protein (TSPO) and myoinositol (mIns), comparing levels in subjects scanned post-pandemic versus scanned pre-pandemic -- assessment of the link between neuroinflammatory signals (and their localization in the brain) from the scans and scores on a questionnaire assessing mental and physical impacts of the pandemic -- serum levels of cytokines and chemokines were measured from venous blood measurements to evaluate possible links between neural and circulating in...

  A new study assessed the one-year outcome of hospital survivors in China who had had Covid-19 (see  covid 1 yr outcome after hosp lancet2021 in dropbox , or  doi.org/10.1016/S0140-6736(21)01755-4 )    Details:  -- 1276 Covid-19 survivors who were in the Jin-Yin-Tan hospital between January 7 and May 29, 2020, then followed at 6 months and 12 months (58% of the 2469 people discharged from the hospital completed the 6- and 12-month follow-up visits)  -- mean age 59, 53% men, never smoker 82%/current smoker 7%/former smoker 11% , hypertension 36%/diabetes 15%/coronary heart disease 8%  -- Covid-19 severity scale: hospitalization not requiring supplemental oxygen  (scale 3) in 25%; hospitalization requiring supplemental oxygen (scale 4) in 68%; hospitalization requiring high flow oxygen by nasal cannula or nasal cannula oxygen  non-invasive mechanical ventilation (scale 5) in 7%; hospitalization requiring ECMO or IMV (scal...