geoffrey modest medical blogs

  A recent study found that lenacapavir was a very effective med to prevent HIV infection in cisgender women (see   hiv pre-exp proph lenacapavir cisgender women NEJM2024  in dropbox, or DOI: 10.1056/NEJMoa2407001   Details : -- 5338 HIV-negative women in South Africa and Uganda were recruited into a phase 3, double-blind, randomized controlled trial of 3 groups to assess pre-exposure prophylaxis against HIV (PrEP):     -- subcutaneous lenacapavir 927mg every 26 weeks (with a window of up to 7 days) plus placebo tablets for F/TAF and F/TDF     -- daily oral F/TAF (emtricitabine-tenofovir alafenamide) plus placebo injections     -- daily oral F/TDF (emtricitabine-tenofovir disoproxil fumarate) plus placebo injections, serving as an active control -- the background in these countries: at least 3.5 adolescent girls and young women per 100 person-years developed incident HIV infections if not using PrEP -- the participants in ...

  A large healthcare database documented significant maternal (and likely fetal) problems associated with Covid-19 infection during pregnancy (see   covid pregnancy outcomes jamaintmed2021   in dropbox, or  https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2775396  )   Details : -- data from the Premium Healthcare Database, an all-payer database including 20% of US hospitalizations, from April 1 to November 23, 2020 -- mean age 29 (25% <25yo, 55% 25-34yo, 18% 35-44yo) -- 6380 (1.6%) of women had Covid-19 versus 400,066 women who did not     -- the biggest differences between these groups: those with Covid were more often Black (18% versus 15%), Hispanic (43% versus 18%), less often white (28% versus 57%); more often from the Northeast (25% versus 15%), less often from the Midwest (15% versus 23% or West 12% versus 16%)     -- comorbidities: more often obesity 17% versus 15% and gestational diabetes 11% versus 10%,...