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Showing posts with the label IL-6

COVID: negative hydroxychloroquine study

another observational (but better) study on hydroxychloroquine is in pre-print and pre-peer-reviewed form ( see  covid hydroxychloroquine not help france2020  in dropbox, or  https://www.medrxiv.org/content/10.1101/2020.04.10.20060699v1.full.pdf  ) Details: --181 patients were from 4 French tertiary-care hospitals, all with documented SARS-CoV-2 pneumonia and needing at least 2L/min of oxygen. --they compared  84 patients on hydroxychloroquine (HCQ) 600 mg/d vs 97 not on it, hospitalized between March 17-31     --mean age 60, 71% men, oxygen sat 92%, CRP>40mg/L in 86% --exclusion criteria included starting HCQ prior to hospitalization, or using other experimental drug within 48 hrs of admission (tocilizumab, lopinavir/ritonavir, remdesivir) or steroids --mean of 7 days from symptom onset to hospitalization --HCQ group received med within 48 hours of admission --almost all had bilateral pneumonia and 75% moderate or severe lu...