vitamin d: no dec OA, dec insulin, more preeclampsia
3 recent articles on vitamin d (there are lots of them in the dropbox) 1. JAMA article (see vit d knee OA progression not help in dropbox ) which randomized 146 people twith symptomatic knee osteoarthritis to high dose vitamin d (2000 IU/d) vs placebo for 2 years and evaluated symptoms and progression of cartilage loss. results: -baseline vit d increased from 23 ng/ml to 39 ng/ml with therapy -nonsignificant decrease in sx in vit d group vs placebo -nonsignificant diff in cartilage volume loss, with sl less volume loss in vit d group -if look at subset with lower vit d at baseline, more improvement in both sx and cartilage with vit d than with placebo, but still nonsignificant so, not so impressive results. reasons? maybe vit d is overrated. maybe better to treat people before they get symptomatic OA. maybe better results if patients with lower baseline vit ...