sustained PPI use and subsequent dementia
A new article (preprint, pre-peer review) found that a high cumulative dose of proton pump inhibitors (PPIs) is associated with increased risk of dementia (see ppi and dementia neurol2023 in dropbox, or DOI: 10.1212/WNL.0000000000207747) Details : -- 5712 dementia-free participants were evaluated from the community-based ARIC study (Atherosclerosis Risk in Communities Study), enrolled from 1987-89 and followed through until 2017 -- the ARIC study recruited patients from four US communities: Washington County, Maryland; Forsyth County, North Carolina; suburbs of Minneapolis, Minnesota; and Jackson Mississippi. -- mean age 74, 58% female, 22% Black/78% white, BMI 29, hypertension 73% , diabetes 34%, APOE e4 carrier 25%, smoking never 38%/former 48%/current 5%, aspirin use 72%, anticholinergic use 1%, vitamin B12 use 5% , and H 2 receptor antagonists\ use 7% -- baseline characteristics were very similar for PPI users versus nonusers, though the users were more likely to b