Trimethoprim and acute kidney injury in the elderly
Trimethoprim used to treat UTIs in the elderly is associated with excessive hyperkalemia and acute kidney injury (see trimethoprim AKI bmj2018 in dropbox, or https://doi.org/10.1136/bmj.k341 ). Details: --UK electronic primary care records were data-mined for adults >65yo who had at least one urinary tract infection (UTI) treated with antibiotics, from 1997-2015 --178,238 individuals were identified from their Clinical Practice Research Datalink of 1,191,904 people; 422,514 had had UTIs --79% female, median 3 UTIs, evenly spread with about 85,000 UTIs for each 5-year age group from 65 to >85yo, DM 21%/ischemic heart disease 34%/heart failure 12%/htn 61% --baseline renal function: eGFR>60 in 42%/45-59 in 23%/30-44 in 12%/<30 in 4% --exposure to RAS blocker or potassium-sparing diuretic in 35% --antibiotics used for UTIs: --amoxacillin 5% (n=22,543) --trimethoprim ...