geoffrey modest medical blogs

  A recent study found that women with breast cancer who were on cardiotoxic chemotherapy (anthracyclines and/or trastuzumab) had worse cardiac remodeling and function if they had subsequent exposure to air pollution (see  breast cancer air pollution dec cardiac function JAMA2025  in dropbox, or doi:10.1001/jamanetworkopen.2025.52323)   Details : -- 580 female patients were included in this longitudinal prospective cohort study using data from the Cardiotoxicity of Cancer Therapy randomized clinical trial done at multiple sites     -- this trial enrolled women diagnosed with breast cancer between July 1, 2010, and November 1, 2018, from the Abramson Cancer Center at the University of Pennsylvania. All participants were initiating anthracyclines and/or trastuzumab     -- air pollution exposure assessment, which was done prior to chemotherapy: three-year average census tract–level concentrations of fine particulate matter with diameter of 2.5 μ...

  A recent highly publicized article highlighted the increasing prevalence of early-onset colorectal cancer, per the New York Times ( https://www.nytimes.com/2024/03/27/well/colon-cancer-symptoms-treatment.html?unlocked_article_code=1.gk0._FWp.fK3YTcjI4fOo&smid=nytcore-ios-share&referringSource=articleShare&ugrp=m  ), which referenced a recent medical article (see  colon ca early onset review Cancers2023  in dropbox, or  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341111/  )   Details : -- early-onset colorectal cancer (EOCRC), defined as a colorectal cancer (CRC) diagnosis before the age of 50, has been increasing in frequency despite the fact that overall CRC incidence (and mortality) has been decreasing -- this medical article reviews the epidemiology, risk factors, clinicopathological features/prognosis, and treatment of EOCRC   Epidemiology: -- CRC is the third most common malignancy and cause of death globally, with an es...