geoffrey modest medical blogs

  A recent study found that multivitamin-mineral supplementation was associated with improved cognitive function (see   cognitive function better with MVI AmJClinNut2023   in dropbox, or  doi.org/10.1016/j.ajcnut.2023.12.011). This   study   was highlighted in a recent New York Times article: https://www.nytimes.com/2024/01/18/well/live/multivitamin-memory-supplement.html?smid=nytcore-ios-share&referringSource=articleShare  )   Details : -- 21,442 adults in the US aged at least 60 yo  were in a 2 x 2 factorial trial of cocoa extract (500 mg flavanols/d ay   with /or  without  daily multivitamin-mineral supplement (MVM) ,  in the COSMOS study (Cocoa Supplement and Multivitamin Outcomes Study) -- 492 patients participated in the COSMOS-Clinic  subcohort  of the overall study (see description below) and had in-person detailed neuropsychological assessments at baseline and at two years. There are also two other s...

  A recent large study found that a commercial multivitamin-mineral (MVM, Centrum Silver) tablets improved cognitive function (see   cognitive function inc with MVI AlzDem2022   in dropbox, or DOI: 10.1002/alz.12767 ). thanks to Karen Henley for bringing this to my attention   Details : -- the COSMOS-Mind study (Cocoa Supplement and Multivitamin Outcomes Study of the Mind,  COSMOS-m ), an ancillary study to a large pragmatic, placebo-controlled, 2x2 factorial clinical trial of cocoa extract (CE) and/or MVM on cardiovascular and cancer outcomes. patients were enrolled from 2016-17 [a pragmatic trial is more of a real-world trial, often done by phone interviews of patients, instead of a more structured efficacy trial]      -- CE contained 500mg of cocoa flavanols including 80 mg (-)-epicatechins, 50 mg theobromine, and 15 mg caffeine -- 2262 participants (mostly from the Brigham and Women's Hospital i...