postmenopausal bleeding and endometrial cancer
A systematic review and meta-analysis found that postmenopausal bleeding preceded the vast majority of diagnoses of endometrial cancer, though only a small minority of women with postmenopausal bleeding in fact had cancer (see postmenopausal bleeding review jamaintmed2018 in dropbox, or doi:10.1001/jamainternmed.2018.2820 ). Details: --21 studies were found between 1977-2017 that included the analysis of the prevalence of postmenopausal bleeding (PMB) in women with endometrial cancer: 3792 cases of cancer, 3257 of whom had PMB --92 studies were found to assess the risk of endometrial cancer in women with PMB: 31,220 women with PMB, 2611 of whom had cancer Results: --Prevalence of PMB in women with endometrial cancer --overall prevalence of PMB was 90% --similar % if limit study outliers, ie no difference in outcome if less variance between studies --by tumor stage: ...