multivitamins may improve cognition
A recent large study found that a commercial multivitamin-mineral (MVM, Centrum Silver) tablets improved cognitive function (see cognitive function inc with MVI AlzDem2022 in dropbox, or DOI: 10.1002/alz.12767 ). thanks to Karen Henley for bringing this to my attention Details : -- the COSMOS-Mind study (Cocoa Supplement and Multivitamin Outcomes Study of the Mind, COSMOS-m ), an ancillary study to a large pragmatic, placebo-controlled, 2x2 factorial clinical trial of cocoa extract (CE) and/or MVM on cardiovascular and cancer outcomes. patients were enrolled from 2016-17 [a pragmatic trial is more of a real-world trial, often done by phone interviews of patients, instead of a more structured efficacy trial] -- CE contained 500mg of cocoa flavanols including 80 mg (-)-epicatechins, 50 mg theobromine, and 15 mg caffeine -- 2262 participants (mostly from the Brigham and Women's Hospital i...