atorvastatin vs rosuvastatin: better for diabetes outcome??
A recent Korean study (the LODESTAR study) found that rosuvastatin was associated with lower LDL levels than atorvastatin, but rosuvastatin seemed have a higher risk for new onset diabetes requiring medications as well as cataract surgery (see statin rosuv vs atorv BMJ2023 in dropbox, or doi.org/10.1136/bmj‑2023‑075837) Details : -- 4400 adults with clinically diagnosed coronary artery disease (stable ischemic heart disease or acute coronary syndrome) requiring statin therapy, in 12 hospitals in South Korea from 2016 to 2019, in an investigator-initiated, randomized, open label trial (i.e. not drug company sponsored) -- mean age 65, 28% women, 14% current smoker, BMI 25 -- comorbidities: hypertension 67%, diabetes 33%, CKD 7% -- cardiac history: percutaneous coronary intervention 56%, stroke 6%, acute MI in the last year 8%, unstable angina or revascularization in the past year 18%, MI more than one year ago 15%, unstable angina or revascularization more th...