GLP-1 receptor agonists for alcohol dependence??
Here are 2 pretty convincing articles suggesting that GLP-1 receptor agonists (GLP-1RAs) might be important medications to treat alcohol use disorder (AUD) --------------------------------------------------------- 1. a rat study: alcohol dec with semaglutide rats lancet2023 in dropbox, or doi.org/10.1016/j.ebiom.2023.104642 -- male and female rats were studied, rats that were bred to have a voluntary high and stable alcohol consumption that created pharmacologically relevant blood alcohol concentrations -- acute and repeated semaglutide administration led to significant reductions in alcohol intake and prevented relapse-like drinking in both male and female rats (relapses being simulated by withdrawing semaglutide after it had led to decreased alcohol consumption, rats then resuming drinking, then reinitiating semaglutide with good effect) -- there was no decrease in drinking water or total liquid intake (there actu...