Riboflavin for migraine prophylaxis?
A systematic review and meta-analysis found that riboflavin (vitamin B2) has significant benefit in migraine prophylaxis, including decreases in the number of migraine days, duration and frequency (see migraine riboflavin prophy NutrNeurosci2022 in dropbox, or doi.org/10.1080/1028415X.2021.1904542 ) Details : -- nine articles were included in this systematic review and meta-analysis: eight randomized controlled trials and one controlled clinical trial were analyzed, with an overall total of 678 individuals -- the overall sample sizes ranged from 26-130 adult subjects with varying doses of riboflavin -- the intervention groups were on 400 mg of vitamin B2 daily in eight studies , 100 mg in one -- four of the studies compared vitamin B2 to other migraine prophylactics (propranolol 80 mg, valproate 500 mg, metoprolol 200 mg or bisoprolol 10 mg, and aspirin 75 mg) -- overall these studies were felt to have l...