geoffrey modest medical blogs

  A recent analysis of the Nurses’ Health Studies and Health Professionals' Follow-up Study revealed a relationship between consuming red meat and the development of diabetes in men and women (see   dm red meat AmJClinNut2023  in dropbox or  https://doi.org/10.1016/j.ajcnut.2023.08.021   ) Details : -- 216,695 participants from the combination of the Nurses’ Health Study, Nurses’ Health Study II, and Health Professionals Follow-up Study, all having relied on detailed assessments of their dietary intake, with food frequency questionnaires every 2 to 4 years that semiquantitatively comprised 61 food items initially, which increased in 1984 to 120 items      -- the studies were started in 1976-1989, with follow-up until at least 2016      -- 5,483,981 person-years of follow-up were evaluated for intakes of total, processed (eg, hotdogs, bacon), and unprocessed red meat -- mean age at baseline 36-53yo (all of these baseline va...

  A recent study found that antibiotic -resistant microbes  can  spread  to the broader community not exposed to antibiotics (see  microbiome population effect of antibiotics NatCommunic2023  in dropbox, or  doi.org/10.1038/s41467-023-36633-7 )    Details :  -- 8972 human microbiome samples were analyzed, the vast majority from the gut microbiome (7589  of them) , analyzing  the amino acid spans of DNA that help with predicting actual gene function (for those in the know,  the open reading frames or ORFs)     -- the study focused on 3096 gut microbiomes from healthy individuals not taking antibiotics, assessing  them for  many of the  known  antimicrobial resistance genes (ARGs)          --  healthy individuals  were defined as  those with out  C difficile infections, cholera, colorectal adenomas  and  cancer, inflammat...