Candida auris: old but new treatment
A recent article found that the combination of lopinavir with an azole antifungal (itraconazole) may effectively treat multidrug-resistant Candida species, including C. auris, which has recently come to light as a huge potential problem (see candida auris lopinavir plus azole works antimicagentchemo2020 in dropbox, or DOI: 10.1128/AAC.00684-20 ) Details: -- this is basically a laboratory study, so I will not go into lots of detail -- they assessed fluconazole chemosensitization by 1,547 FDA approved drugs and clinical molecules against azole-resistant C. aureus Results: --lopinavir exhibited potent synergistic interactions with azole drugs, especially with itraconazole but also with fluconazole and voriconazole (lopinavir's combination with itraconazole worked on all C. auris clades, fluconazole only on clade 1, and voriconazole worked only on clades 1 ...