geoffrey modest medical blogs

  A recent article confirmed that bacterial vaginosis is a sexually transmitted infection, and recurrent infections in women can be decreased by treating their male partners (see   bacterial vaginosis treat male NEJM2025  in dropbox, or DOI: 10.1056/NEJMoa2405404)   Details: -- open-label, randomized, controlled trial of women in Australia who had bacterial vaginosis and were in a monogamous relationship with a male partner -- partner-treatment group: women received first-line recommended antimicrobial agents (metronidazole 400 mg tablets twice daily for seven days, or, if contraindicated, intravaginal  2% clindamycin cream for seven nights or intravaginal 0.75% metronidazole cream for five nights), and male partner had oral metronidazole 400 mg and 2% clindamycin cream applied to the penile skin, both twice a d​ay for seven days -- control group: women received the above treatment, and the partner received no treatment (this was an open-label trial because of c...

  A recent article reviewed the clinical presentations and epidemiology of monkeypox infections worldwide ( see  monkeypox clinical presentation NEJM2022 in  dropbox, or DOI: 10.1056/NEJMoa2207323 )      Details :  -- 528 infections (confirmed by PCR) diagnosed between April 27 and June 24, 2022 at 43 sites in 16 countries (90% from    Europe and 6% from North America, but also from Argentina and Israel)  -- those infected: 98% gay or bisexual men, 75% white, median age 38, 41% had HIV infection (controlled: in 97% with HIV VL <200, CD4 680)  -- concomitant sexually transmitted infection: 109/377 (29%): 33 with syphilis (9%), 32 gonorrhea (8%), chlamydia 20 (5%), others 1% each)  -- positive hepatitis C antibody: 30 (6%)  -- history of smallpox vaccination: 49 (9%)  -- transmission: 95% through sexual activity       -- median number of sex partners in prior 3 months: 5  -- clinica...