gastroparesis: high placebo/nocebo response rates
A recent systematic review and meta-analysis evaluated the placebo response and adverse event rates in treatments for gastroparesis (see placebo response rate in gastroparesis ClinGastroHep2023 in dropbox, or doi.org/10.1016/j.cgh.2022.09.033 ) Details : -- the medical literature was reviewed through August 2022 to identify RCTs comparing active drug with placebo in patients with gastroparesis -- placebo response rates were assessed for at least one of nausea, vomiting, abdominal pain, bloating, or fullness (typical gastroparesis symptoms), as well as for adverse events. -- 22 articles reported on the placebo response rates, with a total of 1011 patients -- Primary outcome: magnitude of the placebo response as well as adverse events associated with placebo (i.e. the nocebo effect: adverse events associated with the belief that the placebo will cause harm) Results : -- overall pooled placebo response rate: 29.3% (23.7%-35.2%) ...