OUD in pregnancy: buprenorphine better than methadone
A large study found that infants born to mothers with opioid use disorder on buprenorphine did better than if they were on methadone, though no difference in maternal outcomes (see opioid use disorder pregnancy bup better than methadone nejm2022 in dropbox, or DOI: 10.1056/NEJMoa2203318 ) Details : -- data-mining study of 2,548,372 pregnancies of women in Medicaid programs in the US who had opioid use disorder (OUD) and were on buprenorphine (BUP) or methadone (MET), from 2000-2018 -- mean age 29, 83% white/5% Black, 70% used opioids prior to pregnancy, tobacco use 45% -- baseline anxiety 30%, depression 27%, bipolar 11%; antidepressants 5%,benzos 19% -- adequacy of prenatal care: inadequate 44%, intermediate 17%, adequate 15%, adequate plus 24% -- women on BUP were more often white, from the Northeast or Midwest, and live in nonmetropolitan or rural areas. Also more likely to have depression or anxiety and have nonopioid substanc...