geoffrey modest medical blogs

  A post hoc analysis of the Look AHEAD study, which involved extensive nonpharmacologic therapies for those with diabetes, found that individuals achieving diabetes remission had significantly decreased incidence of chronic kidney disease (CKD) and cardiovascular disease (CVD): see  dm remission dec CKD CVD Diab2024  in dropbox, or  doi.org/10.1007/s00125-023-06048-6 Background information on the Look AHEAD study: -- the Look AHEAD study is a multicenter RCT assessing the effect of a 12 year intensive lifestyle intervention in individuals with diabetes, finding that diabetes remission occurred in 12% of all intervention participants and also that 21% of those with fewer than two years of diabetes duration achieved remission the first year and 10% achieved two years of remission (remission was assessed annually) -- the Look AHEAD study,  a multicenter RCT assessing the effect of a 12 year intensive lifestyle intervention in individuals with diabet...

  A recent large retrospective case-control study found that long-term exposure to ADHD medications was associated with an increased risk of hypertension and arterial disease (see   ADHD meds inc CVD risk JAMAPsych2024  in dropbox, or  doi:10.1001/jamapsychiatry.2023.4294)   Details : -- 278,027 individuals aged 6 to 64 years old with an diagnosis of incident ADHD were identified  and  10,388 also had cardiovascular disease (CVD) ,  from 2007 and 2021     -- data on ADHD and CVD diagnoses were obtained from the Swedish National Inpatient Register and  data on  ADHD medications dispensed were from the Swedish Prescribed Drug Register     -- cases selected included individuals with ADHD and an incident CVD diagnosis (ischemic heart disease, cerebrovascular disease, hypertension, heart failure, arrhythmias, thromboembolic disease, arterial disease)     --  these  10,388 individuals with...