high dose flu vaccine in elderly is best
A recent Danish study found that elderly patients given the high-dose influenza vaccine had reduced incidence of cardiorespiratory hospitalizations when compared to those given the standard-dose vaccine (see influenza vaccine high-dose helps in elderly JAMACardiol2025 in dropbox, or doi:10.1001/jamacardio.2025.3460) Details: --332,438 participants at least 65-year-old were assessed through a prespecified secondary analysis of the DANFLU-2 study, a pragmatic, open-label, individually randomized clinical trial using nationwide administrative health registries in Denmark during the 2022/2023 to 2024/2025 Influenza seasons -- patients were randomized to receiving a high-dose inactivated influenza vaccine (HD-IIV) versus the standard-dose IIV (SD-IIV) -- severe cardiovascular outcomes were prespecified secondary and exploratory endpoints in the DANFLU-2 trial, when occurring at least 14 days after vaccination and through May 31 of the following year -- there were no formal exclu...