geoffrey modest medical blogs

  A recent study reaffirmed a relationship between H Pylori infection in the development of Type II diabetes (see  H pylori and development of diabetes BMCendo2024  in dropbox, or  https://doi.org/10.1186/s12902-024-01694-2 )   Details : -- 4406 participants attending their annual health checkups at a single Chinese hospital were included in this study to assess the correlation between the incidence of Type II diabetes and H. pylori infection.     -- 2053 participants were H. pylori positive as detected by breath test, 2353 were H. pylori negative -- Mean age 48, 37% female -- BMI 24, fasting blood glucose 95 mg/dL, total cholesterol 174/HDL 52/LDL 108 mg/dL -- exclusion criteria included patients with severe hepatic, renal, cardiovascular or cerebrovascular diseases; those with malignant tumors or autoimmune diseases; and those with other endocrine disorders   -- main outcomes: assess the correlation between the incidence of Type II diabetes and H Pylori infection;  assess the potenti

  A recent study found that a single initial measurement of LDL cholesterol, high-sensitivity C-reactive protein, and Lipoprotein (a) was predictive of future cardiovascular events 30 years later (see   cad women inflam chol lip(a) 30 yr NEJM2024  in dropbox, or DOI: 10.1056/NEJMoa2405182.   Details: --39,876 US female health professionals in the Women’s Health Study (WHS), a prospective cohort of healthy US women at least 45 years old who were randomized to low-dose aspirin or vitamin E, enrolled from 1992-1995     -- these women were followed for 10 years with this intervention, but then continued to have followup prospectively through 2023, allowing for assessment of 30-year outcomes     -- 27,939 women in this cohort volunteered to have baseline blood drawn and stored in liquid nitrogen, later being assessed for high-sensitivity CRP levels (hs-CRP), LDL cholesterol, and Lipoprotein (a) (LP(a)) -- baseline demographics/etc:     -- mean age 55     -- hypertension in 25%, diabetes 2.5