geoffrey modest medical blogs

  A Swedish study found that following men with a high PSA with an MRI seemed to be a reasonable approach for risk-stratifying patients, decreasing false positive results and without leading to significant delays in diagnosis of significantprostate cancer, in the Gothenburg-2 trial, a large, population-based, screening trial (see psa MRI followup NEJM2024  in dropbox, or DOI:10.1056/NEJMoa2406050). Special thanks to Brittany Berk (a really smart urologist and, it just so happens, my daughter-in-law) for some comments and suggestions.....   Details: -- about 80,000 men who were 50 to 60 years of age in Gothenburg (aka “Goteborg”), Sweden were eligible for participation in the trial, from which 38,316 men were randomly selected and invited for screening, a population-based trial that started in 2015 -- those who accepted the invitation were assigned in a 1:1:1 manner to 1 of 3 groups:     -- those with low PSA levels of 1.8-3.0 ng/mL.  these men were followed but were not targeted in the

  A recent data-mining study found that smokers taking semaglutide had decreased tobacco use (see   smoking cessation semaglutide AIM2024  in dropbox, or doi:10.7326/M23-2718)   Details : -- 222,942 new users of diabetes medicines, including 5967 prescribed semaglutide versus seven other diabetes medications, were evaluated regarding three tobacco use disorder (TUD)-related healthcare measures: medical encounters for the diagnosis of TUD, smoking cessation medication prescriptions, and smoking cessation counseling, from 2017 to 2023     -- these patients were identified in the TriNetX database, a global, federated, health research network providing access to de-identified and aggregated electronic health records of approximately 113 million patients and 64 large healthcare organizations covering diverse geographic regions, age, race, ethnicity, income and insurance groups, and clinical settings         -- the TriNetX platform has been used to assess several other relationships between