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low cystatin-c vs creatinine predicts bad outcomes

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  A new meta-analysis confirmed the rather common finding of significant discordance between estimated GFR (eGFR) by cystatin vs creatinine, finding that when eGFR was significantly lower by cystatin, there were significant increases in all-cause mortality, cardiovascular events, and kidney failure (see  ckd cystatin better than creat JAMA2025  in dropbox, or doi:10.1001/jama.2025.17578)   Details : -- the data source for this meta-analysis was the Participants in the Chronic Kidney Disease Prognosis Consortium (CKD-PC), focusing on participants with concurrent Cystatin-C (referred to as cystatin below) and creatinine measurements (eGFRcys and eGFRcr, respectively) and clinical outcomes, using an individual-level meta-analysis -- 23 outpatient cohorts: total of 821327 individuals     -- mean age 59, 48% female, 13.5% with diabetes, 40% with hypertension     -- mean eGFRcr 87, mean eGFRcys 81, median eGFRcys-eGFRcr difference of -5.4%, me...
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hyperparathyroidism: surgery decreases diabetes risk

  A recent article found that patients with primary hyperparathyroidism have reduced type II diabetes if they had parathyroidectomy over medical therapy, in this retrospective cohort study from Israel (see   hyperparathyroid surgery dec diabetes  in dropbox, or doi:10.1001/jamanetworkopen.2025.46222)   Details : -- 50,199 patients who were diagnosed with primary hyperparathyroidism  (pHPT)  from 2000-2024 in the Clalit Health Services database, a nationwide databank of Israel’s largest healthcare organizations. These patients were compared to 150,265 controls who were matched for age, sex, and socioeconomic status. Those having secondary hyperparathyroidism were excluded     -- the Clalit database includes information on diagnoses, hospitalizations, clinical visits, demographic characteristics, laboratory values, and medications. this database has a remarkably low patient turnover rate (1%), allowing for long-term follow-up -- 6654 of these p...
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