early vascular risk factors for later dementia
a recent article assessed long-term vascular risk factors associated with future incident dementia, quantifying the early presence of hypertension, diabetes, and smoking to the subsequent development of dementia both before and after age 80, taking into account apolipoprotein ε4, and calculating the population attributable fractions (PAFs) for these risk factors individually and in combination: see dementia early risk for later dementia JamaNeuro2025 in dropbox or doi:10.1001/jamaneurol.2025.1495 Details : -- 7731 participants in the Atherosclerosis Risk and Communities (ARIC) study with 33 years of follow-up from 1987 to 2020, in the current ARIC-NCS study (ARIC-Neurocognitive Study) -- this study included participants from Jackson, Mississippi; Forsyth County, North Carolina; Minneapolis suburbs, Minnesota; and Washington County, Maryland -- these sites reflected significant diversity in terms of socioeconomic factors, including rac...