geoffrey modest medical blogs

  A recent article found that patients with primary hyperparathyroidism have reduced type II diabetes if they had parathyroidectomy over medical therapy, in this retrospective cohort study from Israel (see   hyperparathyroid surgery dec diabetes  in dropbox, or doi:10.1001/jamanetworkopen.2025.46222)   Details : -- 50,199 patients who were diagnosed with primary hyperparathyroidism  (pHPT)  from 2000-2024 in the Clalit Health Services database, a nationwide databank of Israel’s largest healthcare organizations. These patients were compared to 150,265 controls who were matched for age, sex, and socioeconomic status. Those having secondary hyperparathyroidism were excluded     -- the Clalit database includes information on diagnoses, hospitalizations, clinical visits, demographic characteristics, laboratory values, and medications. this database has a remarkably low patient turnover rate (1%), allowing for long-term follow-up -- 6654 of these p...

  A recent Chinese study found that changing regular salt to a salt substitute with 75% sodium chloride and 25% potassium chloride in patients with a prior stroke was associated with a reduced risk of stroke recurrence and death: see   htn salt substitute dec stroke JAMAcardiol2025  in dropbox, or doi:10.1001/jamacardio.2024.5417, in a subgroup analysis of the SSaSS   study  (Salt Substitute and Stroke Study)   Details: --15,249 people who had had a self-reported stroke in 600 Northern Chinese villages in this open-label, cluster randomized clinical trial     -- these villages were randomized to either continuing regular salt (100% sodium chloride) versus a salt substitute (75% sodium chloride and 25% potassium chloride) --baseline data was collected on participants of their demographics, disease history, medication use, and salt-related knowledge and behaviors; also 24-hour urinary sodium and potassium excretions were measured alon...