aspirin increases risk of heart failure
A recent article documented the increased risk of heart failure in people on aspirin therapy (see aspirin inc chf ESCHF2021 in dropbox in dropbox, or DOI: 10.1002/ehf2.13688) Details: -- 30,827 patients at risk for heart failure (HF) were in 6 observational studies and were on aspirin at baseline (ASCOT, FLEMENGHO, HEALTH ABC, HULL LIFELAB, PREDICTOR and PROSPER studies) . For this study, these patients were divided into a derivation set of data from ASCOT, and validation set from the other 5 studies -- mean age 69, 34% women -- 22% diabetic, 26% current smokers, 67% alcohol consumption, BP 157/89 mmHg, HR 70, BMI 28, total cholesterol/HDL ratio 4.6 -- MI in 3%, coronary heart disease 26%, stroke 10%, atrial fibrillation 1%; 25% on aspirin (total of 7698 people on aspirin) -- follow-up 5.3 years (2.1-11.7 yrs) --1330 patients developed HF in the course of the study -- Primary outcome: composite of fatal and non-fatal H F Results:...