oral fluconazole in pregnancy and spontaneous abortion: FDA safety alert
t he FDA just posted a drug safety alert on the use of fluconazole in pregnancy (see http://www.fda.gov/downloads/Drugs/DrugSafety/UCM497705.pdf ), based on a recent JAMA article (see fluconazole and spontaneous abortion jama2016 in dropbox, or Molgaar-Nielsen D. JAMA2016; 315: 58). details of the JAMA study: --a Danish nationwide registry-based cohort study from 1997-2013, of 1,405,663 pregnancies, looking at the association between oral fluconazole use to treat vaginal candidiasis during pregnancy and spontaneous abortion, and comparing that to use of topical azole antifungals - -demographics: 26% were < age 25, 31% age 25-29, 27% 30-34, 13% 35-39; pretty even distribution of household income by quintiles, and pretty equal level of education --results: --86% had cumulative dose of fluconazole of 150-300mg, first dose at median 69 days of gestation ...