geoffrey modest medical blogs

  A new clinical guideline by the Kidney Disease: Improving Global Outcomes (KDIGO) on the evaluation and management of chronic kidney disease: see   ckd kdigo guidelines AnnIntMed2025  in dropbox, or doi:10.7326/ANNALS-24-01926   Overview : -- these guidelines pertain to all patients with chronic kidney disease (CKD) who are not on kidney replacement therapy (KRT), with the current synopsis referring to their highest recommendations and some upgraded practice points that have evolved since 2012 (these practice points are based on expert opinion) -- the guidelines emphasize a tailored-care approach, which does vary over the life course from infants to old age -- they note that these guidelines will only be feasible in higher-resource settings, despite being from a "global" organization   Recommendations : -- staging CKD:     -- they encourage routine testing for patients at risk, including those with hypertension, diabetes, multisystem d...

  A population-based observational study found that gabapentinoids (gabapentin and pregabalin) were associated with severe COPD exacerbations (see   gabapentin assoc severe COPD AnnIntMed2024  in dropbox, or  doi:10.7326/M23-0849)   Details: -- a large data-mining study from Québec access ed  three computerized healthcare databases, collecting information on demographics, medical services,  and  dispensed outpatient prescriptions. this included information on medical services for all Québec residents (though one of the databases only included those who did not have private medication insurance, 43% of the population ). These researchers also accessed   information on  all hospitalizations, procedures, and vital statistics including date, cause, and place of death -- there were  some  differences in the demographics and comorbidities of those  individuals  on gabapentinoids ,  based on whether they were used ...