high chol in young people: high cardiovasc risk
A recent large international study found that non-HDL cholesterol was an excellent predictor of cardiac events in the distant future in patients initially free from cardiovascular disease ( see lipid nonHDL lancet2019 in dropbox, or /doi.org/10.1016/ S0140-6736(19)32519-X ) Details: -- 398,846 individuals without baseline cardiovascular disease, from 38 cohorts in the Multinational Cardiovascular Risk Consortium, which includes data from 19 countries across Europe, Australia, and North America -- 49% women, median age 51 -- there were both derivation (199,415 individuals) and validation ( 199,431 individuals) cohorts within this group, the first to determine the relative risks and the second to predict them. --they created a tool to estimate the probabilities of a cardiovascular disease event by the age of 75, dependent on age, sex, and cardiovascular risk factors, as well as modeling the effect of a 50% reduction...