hypertension: another boost for ARB over ACE-I
A recent article found that certain antihypertensives were better than others regarding cognitive impairment (see https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800076/ ) Details : -- a secondary analysis of the SPRINT trial assessed cognitive impairment in those on antihypertensive regimens that stimulated angiotensin II receptors 2 and 4 (ARBs, dihydropyridine calcium channel blockers such as amlodipine and nifedipine , and thiazide diuretics) versus those that inhibited these receptors (ACE inhibitors, beta blockers, and non-dihydropyridine calcium channel blockers such as diltiazem or verapamil ) -- 8685 participants: 2644 (30%) were exclusively on stimulating meds, 1536 (18%) exclusively on inhibiting meds, and 4505 (52%) on mixed antihypertensive regimens -- for details of the SPRINT trial, see http://gmodestmedblogs.blogspot.com/2015/11/tighter-blood-pressure-control-sprint.html , but basically this ...