chronic pelvic pain: gabapentin ineffective
A recent study found that gabapentin was not effective for chronic pelvic pain in women (see chronic pelvic pain gabapentin not help Lancet2020 in dropbox , or doi.org/10.1016/S0140-6736(20)31693-7 ) Details: --306 women with chronic pelvic pain (defined as pain within the true pelvis), with or without dysmenorrhea or dyspareunia, were randomized to gabapentin (up to 2700mg/d) vs placebo for 16 weeks, study done in 2015-19 in 39 UK hospital centers -- inclusion criteria: age 18 to 50, no obvious pelvic pathology at laparoscopy (e.g. macroscopic endometriosis, complex ovarian cyst, ovarian cyst >5 cm, fibroids >3 cm, and dense adhesions) -- dosing regimen: initially 1 capsule (300 mg) daily, increased by 1 capsule every 3 days until the participant perceived adequate pain relief or had side effects, with the goal to maintain the highest tolerated dose until the end of week 16 -- oral opioids and antidepressants were allowed ...