cardiotoxic breast cancer meds: air pollution increases cardiac problems
A recent study found that women with breast cancer who were on cardiotoxic chemotherapy (anthracyclines and/or trastuzumab) had worse cardiac remodeling and function if they had subsequent exposure to air pollution (see breast cancer air pollution dec cardiac function JAMA2025 in dropbox, or doi:10.1001/jamanetworkopen.2025.52323) Details : -- 580 female patients were included in this longitudinal prospective cohort study using data from the Cardiotoxicity of Cancer Therapy randomized clinical trial done at multiple sites -- this trial enrolled women diagnosed with breast cancer between July 1, 2010, and November 1, 2018, from the Abramson Cancer Center at the University of Pennsylvania. All participants were initiating anthracyclines and/or trastuzumab -- air pollution exposure assessment, which was done prior to chemotherapy: three-year average census tract–level concentrations of fine particulate matter with diameter of 2.5 μ...