geoffrey modest medical blogs

  There are concerns that weight loss is associated with a decreased bone mineral density (BMD) and increased osteoporosis, with the attendant clinical problems. In this light a new study found that an energy-reduced Mediterranean diet accompanied by increased physical activity mitigated the BMD decline (see  bmd inc with mediter diet plus exercise  JAMA2025 , or doi:10.1001/jamanetworkopen.2025.3710)   Details : --924 adults aged 55-75yo with metabolic syndrome (as defined by the American Heart Assn, NHLBI, and International Diabetes Federation: hypertension, triglycerides, HDL, fasting blood glucose, and central obesity) who were overweight (BMI 27-29.9, as defined by this study) or obese (BMI 30-39.9) were randomized to an energy-reduced Mediterranean diet and increased physical activity versus an ad libitum Mediterranean diet with no physical activity promotion, as a prespecified secondary analysis of the 3-year PREDIMED-Plus clinical trial in 23 centers in ...

  Prior studies have found a relationship between periodontitis and atrial fibrillation (AF); a recent study found that a causative agent of periodontal disease (especially the highly pathogenic   Porphyromonas gingivalis ) migrated to the left atrium in a way that could explain a causal relationship between periodontitis and the development of AF (see   afib periodontitis cause Circ2025  in dropbox, or   doi.org/10.1161/CIRCULATIONAHA.124.071310  )   Details, in brief -- susceptible mice were infected with  P gingivalis , inoculated into the pulp of their molars to see if the  P gingivalis  was found in the left atrium --  intracardiac stimulation was used to assess  atrial fibrillation (AF) inducibility in these mice -- human left atrial appendage specimens were evaluated pathologically from 68 patients with AF     -- quantitative periodontal severity had been assessed prior to the surgery by PCR  Results:...