tirzeptide good for heart failure preserved EF
A study from the recent Am Heart Assn meeting confirmed that tirzepatide leads to fewer cardiovascular events in patients having heart failure with preserved ejection fraction (HFpEF) and obesity, in the SUMMIT trial, a drug company supported trial (see heart failure preserved tirzep NEJM2024 in dropbox, or DOI: 10.1056/NEJMoa2410027) Details : -- 731 participants who were at least 40yo with heart failure, a left ventricular ejection fraction (LVEF) of at least 50% and a BMI of at least 30 in an international, double-blind RCT were recruited between April 2021 and June 2023 -- all participants had to have a 6-minute walk distance of 100-425 meters; a Kansas City Cardiomyopathy Questionnaire clinic summary score of 80 or less (scores range from 0-100, the higher scores reflecting a better quality of life); and at least one of an elevated N-terminal pro-B type natriuretic peptide (NT-proBNP) level (defined as >200 pg/m...