Aspirin use and prostate cancer


I had sent out a couple of articles in the lancet suggesting that aspirin protected against incident cancer and cancer mortality, including in those with metastatic disease (see aspirin and incident cancer lancet 2012and aspirin cancer mets lancet 2012 in dropbox). New observational study of 6000 men with prostate cancer (localized adeno, rxd with radical prostatectomy or xrt) and followed 70 months found that, irrespective of the prostate ca therapy, those who happened to be taking aspirin had much lower prostate-specific mortality (3% vs 8%), with dec in both disease recurrence and bony mets. The decrease was particularly impressive in those with "high-risk" disease, wtih prostate-specific mortality 4% vs 19%. Although they looked at all anticoag therapies, the effect was primarily seen with aspirin.  See aspirin and prostate cancer jco 2012 in dropbox.  So, observational study, but adds to the lancet studies, and prior studies that aspirin/nsaids help prevent colon cancer.

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