A recent meta-analysis of lipid-lowering shows that remarkably low levels of LDL cholesterol provide clinical cardiovascular benefit with no clear increased harm (see lipids very low LDL benefit JAMAcardiol2018 in dropbox, or doi:10.1001/jamacardio.2018.2258). Details: -- 4 trials were looked at: -- the Cholesterol Treatment Trialists Collaboration (CTTC), a meta-analysis of several RCTs that compared different LDLs achieved through statins, median follow-up of 4.9 years, 1922 vascular events -- 3 RCTs evaluated non-statin LDL lowering therapies: -- IMPROVE-IT study with ezetimibe (n= 18,144), median follow-up 6.0 years, 5104 vascular events -- FOURIER study with the PCSK9 inhibitor evolocumab (n=2,034), median follow-up 2.1 years, 184 vascular events -- RE...
Comments
Post a Comment
if you would like to receive the near-daily emails regularly, please email me at gmodest@uphams.org