aspirin in elderly may increase serious falls
A recent randomized clinical trial found that low-dose aspirin is associated with increased risk of serious falls in the elderly (see aspirin elderly inc serious falls jama2022 in dropbox, or doi:10.1001/jamainternmed.2022.5028 ) Details : -- the ASPREE-FRACTURE study was a sub-study of the Australian component of the larger ASPREE study -- 16,703 community-dwelling volunteers aged at least 70 were recruited from 2010-2014; all were free of cardiovascular disease, dementia, or physical disability at baseline -- median age of 74 (IQR 72-78), 50% were 70-74 years old, 46% 75-84 yo, 5% >84 yo; 55% women; 32% living at home alone, 68% living with family/friends/spouse; BMI 27 -- current smokers 3.4% , current alcohol use 84%, depression 24%, cancer history 20%, hypertension 75%, osteoarthritis 56%, history of a prior broken bone 38% -- frailty (a s defined by the Fried criteria) : not frail 62%/...