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vitamin D assoc with less telomere shortening

  A recent study found that vitamin D supplementation was associated with less telomere shortening, which could foretell deceasing aging effects and associated severe diseases, in a pre-publication paper (see   vit d longer telomeres  AmJClinNut2025  in dropbox, or DOI:   10.1016/j.ajcnut.2025.05.003 )   Details : -- this current study was part of the VITAL study (Vitamin D and Omega-3 trial), a large, randomized, double-blind, placebo-controlled trial with a 2x2 factorial design of vitamin D 3  2000IU/d (equivalent to 50mcg) and/or marine n-3 fatty acids (n-3 FAs)  1 gm/d  for 5 years. randomization was from 2011 to 2014, with intervention until the end of 2017 -- the overall study included 25,871 US females aged at least 55yo and males aged at least 50yo -- the VITAL Telomere study, which included 1054 participants, was designed to assess the effect of these supplements on leukocyte telomere length (LTL)     -- LTL was assess...
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high Lp(a) increases risk of recurrent ASCVD

  A recent study found that in patients with atherosclerotic cardiovascular disease (ASCVD), there was a progressive increase in recurrent cardiac events as lipoprotein(a) levels increased: see   Lp(a) recurrent ASCVD EuropHeartJ 2025  in dropbox. or   doi.org/10.1093/eurheartj/ehaf297 )   Details : -- they accessed the Family Heart Database of US medical claims from 340 million adults between 2012-2022, representing at least 1/2 of the national census population, with lipid data available for about 1/3 of them -- these medical claims included medication use, diagnoses, procedures, and surgeries     -- 273,770 people had diagnosed ASCVD as well as lipoprotein(a) levels, also referred to as Lp(a), measured         -- ASCVD was defined as: evidence of an MI, other acute coronary syndromes, percutaneous coronary interventions (PCI), CABG, stable angina, ischemic stroke, other cerebral vascular disease, TIA, peripheral va...
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